Analysis of serum CYFRA 21-1 concentrations in patients with esophageal cancer

This study was conducted to determine the use of CYFRA 21-1 for patients suffering from esophageal carcinoma. 50 patients with malignant, 50 patients with benign esophageal lesions, 50 healthy persons and 50 patients with benign lung disease were tested for CYFRA 21-1, CEA, CA 72-4 and SCC-antigen s...

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Bibliographic Details
Published inAnticancer research Vol. 20; no. 6D; p. 4899
Main Authors Brockmann, J G, St Nottberg, H, Glodny, B, Sprakel, B, Senninger, N
Format Journal Article
LanguageEnglish
Published Greece 01.11.2000
Subjects
Antigens, Neoplasm - blood
Antigens, Tumor-Associated, Carbohydrate - blood
Biomarkers, Tumor - blood
Carcinoembryonic Antigen - blood
Esophageal Neoplasms - blood
Esophageal Neoplasms - diagnosis
Esophageal Neoplasms - mortality
Humans
Keratin-19
Keratins
Prognosis
Serpins
Survival Rate
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Summary:This study was conducted to determine the use of CYFRA 21-1 for patients suffering from esophageal carcinoma. 50 patients with malignant, 50 patients with benign esophageal lesions, 50 healthy persons and 50 patients with benign lung disease were tested for CYFRA 21-1, CEA, CA 72-4 and SCC-antigen serum concentrations. The patients with esophageal carcinoma underwent follow-up analysis for one year. CYFRA 21-1 (cut-off: 1.40 ng/ml) showed a sensitivity for esophageal carcinoma of 46% at a specificity of 89.3%. There was a tendency for higher serum CYFRA 21-1 concentrations in advanced T-stages. Correlations of CYFRA 21-1 with N or M stages could not be observed. The postoperative course, in terms of survival and tumor free survival showed significant correlation to pre-operative CYFRA 21-1 concentrations. Adjuvant therapy could be monitored by CYFRA 21-1 as well. Clinical tumor recurrence was preceded by CYFRA 21-1 elevation by 3.4 months. We recommend the use of CYFRA 21-1 in cases of esophageal carcinoma, especially in cases of squamous cell carcinoma.
ISSN:0250-7005