Cyclosporine A shows immunosuppressor activity on T lymphocytes from the peripheral blood and synovial fluid of patients with autoimmune arthritis
This work studies the effects of Cyclosporine A (CsA) upon the activation and proliferation of mononuclear cells (MNC) from the peripheral blood (PB) of patients with chronic autoimmune arthritis and from healthy controls, and from the synovial fluid (SF) of patients. In vitro studies of activation,...
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Published in | Clinical and experimental rheumatology Vol. 14; no. 2; p. 145 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Italy
01.03.1996
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Subjects | |
Online Access | Get more information |
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Summary: | This work studies the effects of Cyclosporine A (CsA) upon the activation and proliferation of mononuclear cells (MNC) from the peripheral blood (PB) of patients with chronic autoimmune arthritis and from healthy controls, and from the synovial fluid (SF) of patients.
In vitro studies of activation, proliferation, mRNA expression and lymphokine production were carried out.
We found in the PB and SF MNCs from patients with autoimmune arthritis that CsA inhibits the proliferative response, activation antigen expression, IL-2 mRNA expression and IL-2 production induced by polyclonal mitogens in a dose dependent manner.
CsA blocks lymphocyte activation in PB and SF MNCs from patients with autoimmune arthritis. |
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ISSN: | 0392-856X |