Neuroblastoma presenting as acute lymphoblastic leukemia but correctly diagnosed after orbital fine-needle aspiration biopsy

A 3 1/2-year-old girl with a diagnosis of common acute lymphoblastic leukemia antigen (CALLA)-positive acute lymphoblastic leukemia was noted to be hypertensive and developed a tonic-clonic seizure. Computed tomography scan of the head revealed a right orbital mass. Orbital fine needle aspiration bi...

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Bibliographic Details
Published inJournal of clinical neuro-ophthalmology Vol. 11; no. 3; pp. 158 - 161
Main Authors SLAMOVITS, T. L, ROSEN, C. E, SUHRLAND, M. J
Format Journal Article
LanguageEnglish
Published New York, NY Raven Press 01.09.1991
Subjects
Biological and medical sciences
Biopsy, Needle
Child, Preschool
Female
Humans
Magnetic Resonance Imaging
Medical sciences
Neuroblastoma - diagnosis
Neuroblastoma - pathology
Ophthalmology
Orbital Neoplasms - diagnosis
Orbital Neoplasms - pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus
Human
Nervous system diseases
Malignant hemopathy
Neuroblastoma
Malignant tumor
Orbit(eye)
Case study
Pathology
Eye disease
Fine needle
Biopsy
Diagnosis
Child
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Summary:A 3 1/2-year-old girl with a diagnosis of common acute lymphoblastic leukemia antigen (CALLA)-positive acute lymphoblastic leukemia was noted to be hypertensive and developed a tonic-clonic seizure. Computed tomography scan of the head revealed a right orbital mass. Orbital fine needle aspiration biopsy demonstrated rosette-like arrangements of cells with fibrillar cytoplasmic processes suggesting neuroblastoma. The tumor cells were antineuron-specific enolase positive. The cytologic findings suggested neuroblastoma, a diagnosis confirmed on subsequent work-up. The difficulty in distinguishing neuroblastoma from acute lymphoblastic leukemia in the pediatric patient is discussed in terms of clinical and cytologic features.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0272-846X