Neuropathy in IgM lambda paraproteinemia. Immunoreactivity to neural proteins and chondroitin sulfate

In axonal neuropathies associated with IgM paraproteinemia, reports of antigen specificity of the M-protein are few. A patient with IgM paraproteinemia presented with progressive mononeuritis multiplex. IgM was found deposited in striking amounts in endoneurium and shown to bind specifically to neur...

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Bibliographic Details
Published inActa neuropathologica Vol. 78; no. 1; p. 57
Main Authors Yee, W C, Hahn, A F, Hearn, S A, Rupar, A R
Format Journal Article
LanguageEnglish
Published Germany 1989
Subjects
Aged
Chondroitin Sulfates - immunology
Electrophoresis, Polyacrylamide Gel
Fluorescent Antibody Technique
Humans
Immunoglobulin M - immunology
Immunohistochemistry
Male
Microscopy, Electron
Nerve Tissue Proteins - immunology
Paraproteinemias - immunology
Paraproteinemias - pathology
Peripheral Nerves - blood supply
Peripheral Nerves - pathology
Peripheral Nerves - ultrastructure
Peripheral Nervous System Diseases - immunology
Peripheral Nervous System Diseases - pathology
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Summary:In axonal neuropathies associated with IgM paraproteinemia, reports of antigen specificity of the M-protein are few. A patient with IgM paraproteinemia presented with progressive mononeuritis multiplex. IgM was found deposited in striking amounts in endoneurium and shown to bind specifically to neural proteins and chondroitin sulfates. Direct immune mechanisms, as well as the physical effects of IgM deposition, likely contributed to the development of the neuropathy.
ISSN:0001-6322
DOI:10.1007/BF00687403