Matching for MHC haplotypes results in improved survival following unrelated bone marrow transplantation

• Published in: Bone marrow transplantation (Basingstoke) Vol. 15; no. 3; pp. 381 - 385
• Main Authors: TAY, G. K, WITT, C. S, LESTER, S, LOISEAU, P, TEISSERENC, H, CHAPMAN, J, TAIT, B, DAWKINS, R. L, CHRISTIANSEN, F. T, CHARRON, D, BAKER, D, HERRMANN, R, SMITH, L. K, DIEPEVEEN, D, MALLAL, S, MCCLUSKEY, J
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.03.1995
• Subjects: Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bone Marrow Transplantation - immunology; Bone marrow, stem cells transplantation. Graft versus host reaction; Cell Line, Transformed; Hematologic Diseases - mortality; Hematologic Diseases - therapy; Histocompatibility Antigens Class I - immunology; Histocompatibility Antigens Class II - immunology; Histocompatibility Testing - methods; HLA-DQ Antigens - immunology; HLA-DR Antigens - immunology; Humans; Matched-Pair Analysis; Medical sciences; Polymerase Chain Reaction; Retrospective Studies; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Human; Unrelated donor; Bone marrow; Graft surgical; Haplotype; Survival; Allogeneic system
• ISSN: 0268-3369; 1476-5365

Unrelated bone marrow donor-recipient pairs were assessed retrospectively for matching of the HLA-B, -C region (beta-block) and HLA-DR, DQ region (delta block) of the major histocompatibility complex (MHC) using a new DNA-based method referred to as MHC-block typing. The method utilises non-HLA DNA polymorphisms in the MHC as markers of blocks of ancestral haplotypes. Kaplan-Meier analysis of recipients who were matched at both the beta- and delta-blocks revealed a 6 months survival of 54%. Survival was better than for patients who were matched only by conventional criteria, including SSO-typing for class II.