Serial cytogenetic studies in allografted patients with chronic myeloid leukemia

Serial marrow karyotyping was performed in 31 chronic myeloid leukemia (CML) patients treated with allogeneic bone marrow transplantation (BMT). Of 11 hematological relapses, seven were heralded for up to 20 months by a cytogenetic relapse (characterized by increasing percentages of Philadelphia (Ph...

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Published inBone marrow transplantation (Basingstoke) Vol. 9; no. 4; pp. 263 - 268
Main Authors BILHOU-NABERA, C, BERNARD, P, MARIT, G, VIARD, F, GHARBI, M.-J, WEN, Z, LACOMBE, F, BROUSTET, A, REIFFERS, J
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.04.1992
Subjects
Adolescent
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Bone Marrow Transplantation
Bone marrow, stem cells transplantation. Graft versus host reaction
Chromosome Aberrations
Cytogenetics
Female
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive - surgery
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - genetics
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative - surgery
Male
Medical sciences
Middle Aged
Philadelphia Chromosome
Time Factors
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Human
Treatment
Chronic myelocytic leukemia
Cytogenetics
Homograft
Bone marrow
Exploration
Malignant hemopathy
Resuscitation
Karyotype
Allogeneic system
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Summary:Serial marrow karyotyping was performed in 31 chronic myeloid leukemia (CML) patients treated with allogeneic bone marrow transplantation (BMT). Of 11 hematological relapses, seven were heralded for up to 20 months by a cytogenetic relapse (characterized by increasing percentages of Philadelphia (Ph)-positive metaphases, seen on serial karyotypes). Chromosomal abnormalities additional to the Ph, seen before BMT, were not found again at relapse. Relapses were characterized by clonal evolutions of the Ph-positive cells, likely corresponding to cytogenetic patterns of treatment-induced leukemia [del(5q), del(7q), complex karyotypes] and were different from those generally found in CML evolution. Involvement of chromosome 1 was also frequent. Sporadic Ph-positive metaphases (not seen in repeated karyotypes) were seen only during the first 8 months after BMT.
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ISSN:0268-3369
1476-5365