Metastatic glioblastoma multiforme in cervical lymph nodes. Report of a case with diagnosis by fine needle aspiration

Metastatic glioblastoma multiforme is a rare event usually seen in patients with previous and repeated surgery. Fine needle aspiration from enlarged lymph nodes in a patient with cerebral glioblastoma multiforme showed a highly cellular smear with dispersed single cells and cell clusters. The cells...

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Bibliographic Details
Published inActa cytologica Vol. 37; no. 6; p. 938
Main Authors González Cámpora, R, Otal Salaverri, C, Vázquez Ramirez, F, Salguero Villadiego, M, Galera Davidson, H
Format Journal Article
LanguageEnglish
Published Switzerland 01.11.1993
Subjects
Biopsy, Needle
Cervical Vertebrae
Glial Fibrillary Acidic Protein - analysis
Glioblastoma - diagnosis
Glioblastoma - pathology
Glioblastoma - secondary
Humans
Immunohistochemistry
Lymph Nodes - chemistry
Lymph Nodes - pathology
Lymphatic Metastasis - diagnosis
Lymphatic Metastasis - pathology
Lymphoma - diagnosis
Lymphoma - pathology
Male
Middle Aged
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Summary:Metastatic glioblastoma multiforme is a rare event usually seen in patients with previous and repeated surgery. Fine needle aspiration from enlarged lymph nodes in a patient with cerebral glioblastoma multiforme showed a highly cellular smear with dispersed single cells and cell clusters. The cells had marked pleomorphism, hyperchromasia, coarse chromatin, prominent nucleoli and occasional intranuclear cytoplasmic inclusions. Multinucleate giant cells and marked endothelial proliferation were also seen. The diagnosis of metastatic glioblastoma multiforme was supported by immunohistochemistry, which showed many cells with thick and large cytoplasmic processes with intense immunoreactivity to glial fibrillary acid protein. The differential diagnosis with other metastatic small cell tumors is discussed.
ISSN:0001-5547