The effect of ultraviolet radiation on the generation of plaque-forming cells and on T-suppressor cell activity to sheep erythrocytes

Following the development of a sun simulator it has been shown that, in a murine model, photo-augmentation of sub-erythemal doses of UVB radiation by UVA significantly influences the histological changes that develop in the epidermal layers of the skin. In this model the polyclonal mitogenic respons...

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Bibliographic Details
Published inPhotodermatology Vol. 3; no. 2; p. 64
Main Authors Funnell, S G, Keast, D
Format Journal Article
LanguageEnglish
Published Denmark 01.04.1986
Subjects
Animals
Antibody-Producing Cells - radiation effects
Antigens - immunology
Erythrocytes - immunology
Male
Mice
Mice, Inbred BALB C
Sheep - immunology
Skin - radiation effects
Sunlight - adverse effects
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - radiation effects
Ultraviolet Rays - adverse effects
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Summary:Following the development of a sun simulator it has been shown that, in a murine model, photo-augmentation of sub-erythemal doses of UVB radiation by UVA significantly influences the histological changes that develop in the epidermal layers of the skin. In this model the polyclonal mitogenic responses to phytohemagglutinin (PHA-P), concanavalin A (Con A) and bacterial lipopoly-saccharide (LPS) are largely unchanged following UV-radiation under sun simulator conditions. However, the specific adaptive plaque-forming cell immune response for both IgM and IgG to the T-dependent antigen SRBC (sheep erythrocytes), given intradermally, is suppressed. This suppression can be abrogated in adoptive immune transfer experiments by treating the cells from the inguinal lymph nodes with monoclonal anti Thy-1.2 antibody.
ISSN:0108-9684