Diazald, a newly recognized antimicrobial agent and its spectrophotometric determination

Diazald, a chemical intermediate for the synthesis of biologically active compounds, was found to be a potent in vitro antimicrobial agent against yeasts, yeast-like and filamentous fungi as well as Gram-positive and Gram-negative bacterial strains. Its activity is not inhibited by either para-amino...

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Bibliographic Details
Published inActa microbiologica Hungarica Vol. 39; no. 3-4; p. 317
Main Authors Uri, J V, Scola, F
Format Journal Article
LanguageEnglish
Published Hungary 1992
Subjects
4-Aminobenzoic Acid - pharmacology
Acetates - pharmacology
Anti-Bacterial Agents
Anti-Infective Agents - analysis
Anti-Infective Agents - antagonists & inhibitors
Anti-Infective Agents - pharmacology
Antifungal Agents - analysis
Antifungal Agents - antagonists & inhibitors
Antifungal Agents - pharmacology
Fungi - drug effects
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Microbial Sensitivity Tests
Nitrosamines - analysis
Nitrosamines - antagonists & inhibitors
Nitrosamines - pharmacology
Spectrophotometry
Thiazoles - pharmacology
Tosyl Compounds - analysis
Tosyl Compounds - antagonists & inhibitors
Tosyl Compounds - pharmacology
Yeasts - drug effects
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Summary:Diazald, a chemical intermediate for the synthesis of biologically active compounds, was found to be a potent in vitro antimicrobial agent against yeasts, yeast-like and filamentous fungi as well as Gram-positive and Gram-negative bacterial strains. Its activity is not inhibited by either para-aminobenzoic acid (PABA) or the nitroso group-specific 2-aminothiazole-methoxyimino acetic acid (ATMAA). This suggests that the molecule as such is responsible for the antimicrobial activity. For its quick measurement a sensitive spectrophotometric method has been developed.
ISSN:0231-4622