Immunizing potential of ultraviolet-attenuated cercariae of Schistosoma mansoni in rodent hosts

Schistosoma mansoni cercariae attenuated with ultraviolet (UV) irradiation (254 nm) at a dose of 18 mJ/cm2 induced partial resistance against a homologous challenge in male ICR mice and male Hartley guinea pigs. The reduction in the adult worm burden was 51% and 37% +/- 13%, respectively. On the oth...

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Bibliographic Details
Published inParasitology research (1987) Vol. 79; no. 4; p. 293
Main Authors Kamiya, H, Ozaki, T, Nakayama, H, Inaba, T
Format Journal Article
LanguageEnglish
Published Germany 1993
Subjects
Animals
Disease Models, Animal
Evaluation Studies as Topic
Female
Gerbillinae
Guinea Pigs
Immunization
Larva - immunology
Larva - radiation effects
Male
Mice
Mice, Inbred ICR
Rodentia - immunology
Rodentia - parasitology
Schistosoma mansoni - immunology
Schistosoma mansoni - radiation effects
Schistosomiasis mansoni - immunology
Ultraviolet Rays
Vaccines, Attenuated - immunology
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Summary:Schistosoma mansoni cercariae attenuated with ultraviolet (UV) irradiation (254 nm) at a dose of 18 mJ/cm2 induced partial resistance against a homologous challenge in male ICR mice and male Hartley guinea pigs. The reduction in the adult worm burden was 51% and 37% +/- 13%, respectively. On the other hand, male and female Mongolian gerbils (Meriones unguiculatus) vaccinated with UV-attenuated cercariae exhibited marginal resistance (13% +/- 9% and 22% +/- 10%, respectively). This raises the possibility that gerbils might have an unknown immune-characteristic nature. The usefulness of UV-attenuated cercariae is discussed with respect to the control of the disease.
ISSN:0932-0113
DOI:10.1007/BF00932184