Patterns of serum FSH, LH and hCG after i.m. or i.v. administration of hMG during pituitary suppression

OBJECTIVE -- The study was undertaken to investigate the effects of a commonly used ovarian stimulation regimen on gonadotropin levels. METHODS -- The behavior of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and human chorionic gonadotropin (hCG) was studied after intramuscular (i.m...

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Bibliographic Details
Published inInternational journal of fertility and menopausal studies Vol. 40; no. 2; p. 86
Main Authors Duijkers, I J, Hollanders, H M, Willemsen, W N, de Leeuw, R, Vemer, H M
Format Journal Article
LanguageEnglish
Published United States 01.03.1995
Subjects
Adult
Buserelin - pharmacology
Chorionic Gonadotropin - blood
Estradiol - blood
Female
Follicle Stimulating Hormone - blood
Humans
Injections, Intramuscular
Injections, Intravenous
Kinetics
Luteinizing Hormone - blood
Menotropins - administration & dosage
Menotropins - pharmacology
Pituitary Gland - drug effects
Pituitary Gland - physiology
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Summary:OBJECTIVE -- The study was undertaken to investigate the effects of a commonly used ovarian stimulation regimen on gonadotropin levels. METHODS -- The behavior of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and human chorionic gonadotropin (hCG) was studied after intramuscular (i.m.) and intravenous (i.v.) human menopausal gonadotropin (hMG) administration. Six female volunteers participated in the study. During pituitary suppression with a gonadotropin-releasing hormone (GnRH) agonist (Buserelin), a single dose of hMG (150 IU) was injected i.m. or i.v., in a cross-over design with an interval of 2 weeks. Blood samples were collected frequently after the injection. Serum concentrations of FSH, specific LH and hCG were determined. RESULTS -- After i.m. administration of hMG, a peak FSH concentration of 7.4 +/- 1.3 U/L was reached after 8 (6-24) hours, with a subsequent decrease. At 0.5 hour after i.v. administration, peak FSH values of 30.5 +/- 5.6 U/L were obtained, followed by a decrease to baseline levels within 48 hours. Exogenous LH and hCG were hardly detectable after i.m. administration of hMG. One-half hour after i.v. injection of hMG, a small increase in specific LH levels to 6.7 +/- 2.6 U/L was shown, followed by a decline. hCG concentrations increased after i.v. hMG administration to 7.6 +/- 1.6 U/L.
ISSN:1069-3130