Experimental murine schistosomiasis mansoni: inhibition of neutrophil granulocyte inflammatory reaction

1. The mobilization of neutrophils into the peritoneal cavity following stimulation with sterile mineral oil was studied in normal and schistosome-infected mice. This response was correlated with changes in blood neutrophil counts and with the production and release of medullar granulocytes. 2. The...

Full description

Saved in:
Bibliographic Details
Published inBrazilian journal of medical and biological research Vol. 21; no. 2; pp. 273 - 279
Main Authors SANTOS-DA-SILVA, C, CARVALHO, E. A, GONCALVEZ, M. S, BOROJEVIC, R
Format Journal Article
LanguageEnglish
Published Ribeirão Preto Associação Brasileira de Divulgação Científica 1988
Subjects
Animals
Biological and medical sciences
Cell Movement
Diseases caused by trematodes
Female
Helminthic diseases
Infectious diseases
Inflammation - pathology
Inflammation - physiopathology
Leukocyte Count
Male
Medical sciences
Mice
Mice, Inbred C57BL
Mineral Oil - pharmacology
Neutrophils - pathology
Neutrophils - physiopathology
Parasitic diseases
Schistosomiases
Schistosomiasis mansoni - pathology
Schistosomiasis mansoni - physiopathology
Tropical medicine
Schistosoma mansoni
Rodentia
Granulocyte
Plathelmintha
Inflammation
Experimental animal
Trematod disease
Helminthiasis
Trematoda
Infection
Ripening
Schistosomiasis
Vertebrata
Experimental disease
Mammalia
Mouse
Neutrophile
Helmintha
Bone marrow
Inhibition
Invertebrata
Online AccessGet full text

Cover

More Information
Summary:1. The mobilization of neutrophils into the peritoneal cavity following stimulation with sterile mineral oil was studied in normal and schistosome-infected mice. This response was correlated with changes in blood neutrophil counts and with the production and release of medullar granulocytes. 2. The peritoneal neutrophil inflammatory reaction was considerably reduced in schistosome-infected mice. The medullar pool of mature neutrophils was totally depleted, in spite of an increased number of immature neutrophil precursors. 3. We conclude that the decreased inflammatory response of neutrophils during schistosomiasis is due to the delay of their maturation in the bone marrow. A similar delay has been observed in schistosomal patients. A causal relationship between delay of neutrophil maturation and sensitivity of schistosomal patients to chronic microbial infections is suggested by these data.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0100-879X
1414-431X