Orally and parenterally administered ibuprofen for postoperative adhesion prevention

Adhesion formation was examined in 45 rats that were divided into five groups of 9 animals each: control, oral ibuprofen, intramuscular ibuprofen, intraperitoneal 32% dextran 70, and oral ibuprofen plus intraperitoneal 32% dextran 70. Four weeks after receiving a standard injury, all the animals wer...

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Bibliographic Details
Published inJournal of reproductive medicine Vol. 31; no. 11; p. 1014
Main Authors De Leon, F D, Odom, J, Hudkins, P, Vijayakumar, R, Heine, M W
Format Journal Article
LanguageEnglish
Published United States 01.11.1986
Subjects
Administration, Oral
Animals
Dextrans - therapeutic use
Drug Therapy, Combination
Fallopian Tubes - surgery
Female
Ibuprofen - therapeutic use
Injections, Intramuscular
Injections, Intraperitoneal
Postoperative Complications - prevention & control
Rats
Rats, Inbred Strains
Tissue Adhesions
Uterus - surgery
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Summary:Adhesion formation was examined in 45 rats that were divided into five groups of 9 animals each: control, oral ibuprofen, intramuscular ibuprofen, intraperitoneal 32% dextran 70, and oral ibuprofen plus intraperitoneal 32% dextran 70. Four weeks after receiving a standard injury, all the animals were killed and the adhesions scored blindly. Both the oral and intramuscular ibuprofen groups had significantly less severe adhesion formation (P less than .01) when compared to the control group. Although 32% dextran 70 alone showed no beneficial effect in reducing adhesions, the combination of oral ibuprofen and 32% dextran 70 had the least adhesion formation (P less than .002) when compared to the control group. Oral and intramuscular ibuprofen seem to be equally efficient in reducing postoperative adhesions. Furthermore, the combination of oral ibuprofen and 32% dextran 70 appears to have a synergistic effect.
ISSN:0024-7758
1943-3565