Henoch-Schönlein purpura in rheumatoid arthritis

This is the first report of Henoch-Schönlein purpura associated with permanent joint damage due to rheumatoid arthritis, which was observed in 3 of the 10 adults we treated for Henoch-Schönlein purpura since 1974. Each of 3 women had been admitted with palpable purpura of the lower extremities. The...

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Bibliographic Details
Published inJournal of rheumatology Vol. 21; no. 6; p. 1138
Main Authors Mitsuhashi, H, Mitsuhashi, M, Tsukada, Y, Yano, S, Naruse, T
Format Journal Article
LanguageEnglish
Published Canada 01.06.1994
Subjects
Adult
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - diagnostic imaging
Arthritis, Rheumatoid - drug therapy
Female
Humans
Prednisolone - therapeutic use
Purpura, Schoenlein-Henoch - etiology
Purpura, Schoenlein-Henoch - pathology
Radiography
Wrist Joint - diagnostic imaging
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Summary:This is the first report of Henoch-Schönlein purpura associated with permanent joint damage due to rheumatoid arthritis, which was observed in 3 of the 10 adults we treated for Henoch-Schönlein purpura since 1974. Each of 3 women had been admitted with palpable purpura of the lower extremities. The diagnosis was based on various findings including arthralgia, stiffness, and/or swelling of the joints, and on the results of radiographic, immunofluorescence and other studies. Renal biopsy revealed slight mesangial proliferation in 2 of the patients. The nephropathy did not deteriorate following discharge. However, bilateral swelling of the wrists with destructive joint changes was subsequently observed on radiographs in all patients. Since 2 patients showed positivity for human leukocyte antigen DR4, this antigen may have been a genetic factor in the joint disease in these patients.
ISSN:0315-162X