Simultaneous pancreas and kidney transplantation : a feasible procedure in selected patients

• Published in: Netherlands journal of medicine Vol. 41; no. 5-6; pp. 194 - 207
• Main Authors: VAN OOSTERHOUT, E. C. A. A, VAN DER WOUDE, F. J, LEMKES, H. H. P. J, GOOSZEN, H. G, VAN BRONSWIJK, H, VAN DEN AKKER, P. J, TAMSMA, J. T, TERPSTRA, J. L
• Format: Journal Article
• Language: English
• Published: Alphen aan den Rijn Van zuiden 01.12.1992
• Subjects: Adult; Biological and medical sciences; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - surgery; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - surgery; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Feasibility Studies; Female; Follow-Up Studies; Host vs Graft Reaction; Humans; Immunosuppression; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - surgery; Kidney Transplantation - methods; Male; Management. Various non-drug treatments. Langerhans islet grafts; Medical sciences; Middle Aged; Pancreas Transplantation - methods; Postoperative Complications - epidemiology; Prospective Studies; Treatment Outcome; Endocrinopathy; Human; Urinary system disease; Diabetes mellitus; Renal disease; Transplantation; Terminal; Kidney; Result; Treatment; Combined surgery; Surgery; Renal failure; Pancreas
• ISSN: 0300-2977; 1872-9061

We analyzed the overall results of 24 simultaneous pancreas and kidney transplantations (SPK), performed in our hospital between April 1986 and June 1990. All patients had type I diabetes mellitus and end-stage renal failure. We used bladder drainage of the pancreatic exocrine secretions through a duodenocystostomy. The blood vessels of both grafts were anastomosed to the iliac vessels. The immunosuppressive management was triple-therapy with cyclosporin, azathioprine and prednisone. All organs were transplanted without matching donors and recipients for HLA. At the time of transplantation, mean recipient age was 37 yr; the average duration of diabetes was 22 yr. After disappointing results in the first 4 patients, the pancreas was placed intraperitoneally instead of extraperitoneally and the antibiotic drug regimen was altered. In the second group (n = 20), patient survival was 100%; 1-yr pancreas and kidney graft survival were 65 and 62%, respectively. Duration of hospitalization and pancreas and kidney graft loss were positively correlated with the number of rejection episodes. After 1 yr of follow-up, the mean creatinine clearance was 62 ml/min and the mean HbA1c was 5.5%. Blood glucose levels and oral glucose tolerance tests were also normal. We conclude that patient and graft survival after SPK are satisfactory, although rejection-related morbidity is still a major problem.