Physicochemical studies of the structure and stability of polysaccharide-protein conjugate vaccines

This short review highlights some areas in which spectroscopic methods have been applied to monitor the structure and stability of both the carbohydrate and protein moieties of polysaccharide-protein conjugate vaccines, such as those now in widespread clinical use for protection against Haemophilus...

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Bibliographic Details
Published inDevelopments in biological standardization Vol. 87; p. 143
Main Authors Jones, C, Crane, D T, Lemercinier, X, Bolgiano, B, Yost, S E
Format Journal Article
LanguageEnglish
Published Switzerland 1996
Subjects
Bacterial Outer Membrane Proteins - chemistry
Bacterial Outer Membrane Proteins - immunology
Bacterial Proteins - chemistry
Bacterial Proteins - immunology
Bacterial Vaccines - chemistry
Bacterial Vaccines - immunology
Chemical Phenomena
Chemistry, Physical
Circular Dichroism
Drug Stability
Excipients - pharmacology
Haemophilus Vaccines - chemistry
Haemophilus Vaccines - immunology
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Polysaccharides, Bacterial - chemistry
Polysaccharides, Bacterial - immunology
Tetanus Toxoid - chemistry
Tetanus Toxoid - immunology
Vaccines, Conjugate - chemistry
Vaccines, Conjugate - immunology
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Summary:This short review highlights some areas in which spectroscopic methods have been applied to monitor the structure and stability of both the carbohydrate and protein moieties of polysaccharide-protein conjugate vaccines, such as those now in widespread clinical use for protection against Haemophilus influenzae infection.
ISSN:0301-5149