Preferential nucleolar localization of Cis-DDP in human fibroblasts

The use of complex platinum salts (Cis-DDP) in antitumoral therapy is well known. However the mode of action of this salt remains unknown. The present study was performed with human transformed cells in culture (WI-98-VAD), grown in the presence of Cis-DDP. The intracellular localization of platinum...

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Bibliographic Details
Published inBiomedicine & pharmacotherapy Vol. 37; no. 3; p. 125
Main Authors Berry, J P, Galle, P, Viron, A, Kacerovská, H, Macieira-Coelho, A
Format Journal Article
LanguageEnglish
Published France 1983
Subjects
Cell Nucleolus - metabolism
Cell Nucleolus - ultrastructure
Cells, Cultured
Cisplatin - metabolism
Fibroblasts - metabolism
Humans
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Summary:The use of complex platinum salts (Cis-DDP) in antitumoral therapy is well known. However the mode of action of this salt remains unknown. The present study was performed with human transformed cells in culture (WI-98-VAD), grown in the presence of Cis-DDP. The intracellular localization of platinum was studied by associating the technique of microanalysis by electronic probe (analysis by wavelength dispersion: W. D. S.) and that of fine tissue sections at low temperature: ultracryotomy. The platinum was found to be concentrated mainly in the nucleolar region.
ISSN:0753-3322