HPLC determination of sodium cromoglycate in pharmaceutical dosage forms

A reversed-phase high-performance liquid chromatography (HPLC) method is described for the determination of sodium chromoglycate (SCG) in bulk drug and pharmaceutical dosage forms (capsules, solutions, gels). Aliquots were chromatographed on C18 columns using methanol: phosphate buffer (50:50 v/v) a...

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Bibliographic Details
Published inFarmaco (Società chimica italiana : 1989) Vol. 49; no. 5; p. 375
Main Authors Radulović, D, Kocić-Pesić, V, Pećanac, D, Zivanović, L
Format Journal Article
LanguageEnglish
Published France 01.05.1994
Subjects
Chromatography, High Pressure Liquid - methods
Cromolyn Sodium - analysis
Dosage Forms
Pharmaceutical Preparations - analysis
Spectrophotometry, Ultraviolet
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Summary:A reversed-phase high-performance liquid chromatography (HPLC) method is described for the determination of sodium chromoglycate (SCG) in bulk drug and pharmaceutical dosage forms (capsules, solutions, gels). Aliquots were chromatographed on C18 columns using methanol: phosphate buffer (50:50 v/v) at pH 2.3 as the mobile phase. Detection was performed at 326 nm with a linear range of 0.05-0.5 microgram/ml (r = 0.9999). Recovery values ranged from 99.21 to 106.31% (N = 9). The proposed method is rapid and simple, free from interference by excipient and degradation products, and can be recommended for routine control analysis of sodium chromoglycate commercial products and magistral formulations.
ISSN:0014-827X