A mechanism for limiting reproduction influenza A virus reassortants with incomplete functional compatibility of hemagglutinin and neuraminidase gene products

• Published in: Voprosy virusologiĭ Vol. 43; no. 1; p. 17
• Main Authors: Kropotkina, E A, Rudneva, I A, Rusanova, O S, Varich, N L, Kadoshnikov, Iu P, Gambarian, A S, Kaverin, N V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.01.1998
• Subjects: Animals; Cell Line; Culture Media; Dogs; Hemagglutinin Glycoproteins, Influenza Virus - genetics; Hemagglutinin Glycoproteins, Influenza Virus - physiology; Influenza A virus - enzymology; Influenza A virus - genetics; Influenza A virus - pathogenicity; Influenza A virus - physiology; Kidney - ultrastructure; Kidney - virology; Microscopy, Electron; Neuraminidase - genetics; Neuraminidase - physiology; Virulence - genetics; Virus Replication - genetics

The mechanism of decrease in the level of virus accumulation in reassortants with hemagglutinin (HA) and neuraminidase (NA) genes from different parents is studied. The reassortant viruses and their passage variants do not differ by the rate of virus protein production or their stability in infected...