Effect of physostigmine on cholinesterase activity in different parts of rat brain

Inhibition of acetylcholinesterase (AChE) in the whole brain, cerebellum, pons, frontal cortex, basal ganglia and medulla oblongata of rat brain by physostigmine (CAS 57-47-6) in vitro was studied. Constants characterizing this inhibition namely: binding constant (KI) and bimolecular rate constant (...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 45; no. 6; p. 663
Main Authors Osman, M Y, Abdel Tawab, S M, Sharaf, I A
Format Journal Article
LanguageEnglish
Published Germany 01.06.1995
Subjects
Animals
Brain - drug effects
Brain - enzymology
Cholinesterase Inhibitors - pharmacology
Cholinesterases - metabolism
Kinetics
Male
Physostigmine - metabolism
Physostigmine - pharmacology
Rats
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Summary:Inhibition of acetylcholinesterase (AChE) in the whole brain, cerebellum, pons, frontal cortex, basal ganglia and medulla oblongata of rat brain by physostigmine (CAS 57-47-6) in vitro was studied. Constants characterizing this inhibition namely: binding constant (KI) and bimolecular rate constant (K'2) were determined. The highest values of K'2 were obtained in the cases of pons and medulla oblongata, the parts responsible for the respiratory and vital centers. The difference in the inhibition of AChE in the different parts of the brain could be due to the difference in the grey and white matters contents in these parts.
ISSN:0004-4172