Pharmacokinetics of cytotoxin 14 from Naja naja atra venom

The pharmacokinetics of cytotoxin 14 (CT 14) from Naja naja atra venom was studied with biotin-avidin enzyme-linked immunosorbent assay. The plasma concentration-time curve of CT 14 after bolus i.v. 0.2 mg.kg-1 into rabbits was found to fit a two-compartment open model. T1/2 alpha was 5.8 +/- 0.6 mi...

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Bibliographic Details
Published inZhōngguó yàolĭ xuébào Vol. 13; no. 6; pp. 544 - 546
Main Authors Guo, M P, Wang, Q C, Liu, G F
Format Journal Article
LanguageChinese
Published Beijing Science Press 01.11.1992
Subjects
Animals
Biological Availability
Cytotoxins - isolation & purification
Cytotoxins - pharmacokinetics
Cytotoxins - toxicity
Elapid Venoms - chemistry
Elapid Venoms - isolation & purification
Elapid Venoms - pharmacokinetics
Elapid Venoms - toxicity
Enzyme-Linked Immunosorbent Assay - methods
Female
Lethal Dose 50
Male
Mice
Rabbits
Rats
Rats, Wistar
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Summary:The pharmacokinetics of cytotoxin 14 (CT 14) from Naja naja atra venom was studied with biotin-avidin enzyme-linked immunosorbent assay. The plasma concentration-time curve of CT 14 after bolus i.v. 0.2 mg.kg-1 into rabbits was found to fit a two-compartment open model. T1/2 alpha was 5.8 +/- 0.6 min and T1/2 beta was 3.5 +/- 0.2 h. A rapid absorption was seen after im injection (0.5 mg.kg-1) to rabbits. The peak level was 260 +/- 90 ng.ml-1 and Tpeak was 13.6 +/- 2.4 min. The absolute bioavailability was 34 +/- 9%. It was shown that CT 14 was absorbed by gut. The peak level was 75 +/- 15 ng.ml-1 after a gastric gavage of 50 mg.kg-1 to rats.
ISSN:0253-9756