Apoptosis and necrosis occurring during different stages of primary and metastatic tumor growth of a rat mammary adenocarcinoma

The pattern of spontaneous apoptosis and necrosis was investigated in an untreated, transplantable rat mammary adenocarcinoma (MTLn3) throughout the natural course of primary and metastatic tumor growth. The occurrence of spontaneous apoptosis was different when comparing primary to metastatic tumor...

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Bibliographic Details
Published inAnticancer research Vol. 16; no. 3A; p. 1117
Main Authors Matsuda, H, Strebel, F R, Kaneko, T, Stephens, L C, Danhauser, L L, Jenkins, G N, Toyota, N, Bull, J M
Format Journal Article
LanguageEnglish
Published Greece 01.05.1996
Subjects
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Animals
Apoptosis - physiology
Cell Division - physiology
Female
Lymph Nodes - pathology
Lymphatic Metastasis
Mammary Neoplasms, Experimental - pathology
Mitosis
Necrosis
Neoplasm Metastasis
Neoplasm Staging
Neoplasm Transplantation
Rats
Rats, Inbred F344
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Summary:The pattern of spontaneous apoptosis and necrosis was investigated in an untreated, transplantable rat mammary adenocarcinoma (MTLn3) throughout the natural course of primary and metastatic tumor growth. The occurrence of spontaneous apoptosis was different when comparing primary to metastatic tumor growth. In the primary MTLn3 tumor growing at the mammary fat pad inoculation site we observed an inverse association between tumor growth and apoptosis. As the primary tumor increased in size, the extent of spontaneous apoptosis decreased. In contrast, an increase in apoptosis was associated with tumor growth of MTLn3 metastases in the axillary lymph node and the lung. In regard to necrosis, a similar pattern of increased necrosis was associated with tumor progression in both primary and metastatic tumors. Differences between primary and metastatic tumors in their pattern of spontaneous apoptosis may have important implications for the design of clinical treatment strategies.
ISSN:0250-7005