Antimycobacterial activity of some 2,3-dianilinoquinoxaline derivatives

The antimycobacterial activity of 2,3-dianilinoquinoxaline derivatives was studied and the substances were found to be mostly wide-spectrum antimycobacterial agents. Replacement of one nitrogen atom in the heterocycle for oxygen or sulfur was usually accompanied by loss of activity. The model struct...

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Bibliographic Details
Published inPharmazie Vol. 52; no. 10; p. 797
Main Authors Waisser, K, Beckert, R, Slosáfrek, M, Janota, J
Format Journal Article
LanguageEnglish
Published Germany 01.10.1997
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Summary:The antimycobacterial activity of 2,3-dianilinoquinoxaline derivatives was studied and the substances were found to be mostly wide-spectrum antimycobacterial agents. Replacement of one nitrogen atom in the heterocycle for oxygen or sulfur was usually accompanied by loss of activity. The model structure for the study was the wide-spectrum antimycobacterial drug clofazimine.
ISSN:0031-7144