Cytoprotective activity of deboxamet: a possible interference with prostaglandin and prostacyclin metabolism in rat gastric mucosa

Deboxamet (5-methoxy-2-methyl-3-indolyl-acetohydroxamic acid) is a new synthetic drug with anti-ulcer and anti-secretory activity. The authors evaluated the ability of deboxamet to protect the rat gastric mucosa against the intensive necroses induced experimentally by absolute ethanol, NaCl (25%), H...

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Bibliographic Details
Published inInternational journal on tissue reactions Vol. 10; no. 3; p. 149
Main Authors Franzone, J S, Cirillo, R, Cravanzola, C
Format Journal Article
LanguageEnglish
Published Switzerland 1988
Subjects
Animals
Anti-Ulcer Agents - pharmacology
Blood Pressure
Carbenoxolone - pharmacology
Epoprostenol - metabolism
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
In Vitro Techniques
Indoles - pharmacology
Male
Mesenteric Arteries - drug effects
Necrosis
Platelet Aggregation Inhibitors
Prostaglandins - metabolism
Rabbits
Rats
Rats, Inbred Strains
Sialoglycoproteins - pharmacology
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Summary:Deboxamet (5-methoxy-2-methyl-3-indolyl-acetohydroxamic acid) is a new synthetic drug with anti-ulcer and anti-secretory activity. The authors evaluated the ability of deboxamet to protect the rat gastric mucosa against the intensive necroses induced experimentally by absolute ethanol, NaCl (25%), HCl (0.6 N), acetylsalicylic acid plus HCl, and sodium taurocholate plus HCl. Deboxamet, as compared with pirenzepine, sulglycotide and PGE2, displayed a cytoprotective activity against these necrotizing agents. The involvement of deboxamet with prostacyclin metabolism was also investigated. In order to assess the presence of PGI2-like substances, extracts of mucosa from rats treated orally with deboxamet and sulglycotide were assayed i) on isolated rabbit mesenteric artery, ii) for hypotensive effect in anaesthetized rat, and iii) for anti-platelet activity. Deboxamet, like sulglycotide, was able to raise the availability of prostacyclins in the rat gastric mucosa, which is an important action in maintaining its cellular integrity. However, our results cannot determine whether this activity is due to an enhanced biosynthesis or a decreased degradation of prostacyclins.
ISSN:0250-0868