Effects of acute amphetamine treatment on the butyrylcholinesterase activity in adrenal glands of mice

Butyrylcholinesterase (BChE, EC 3.1.1.8.) activity in adrenal cortex and medulla was studied in control mice and in mice treated with DL-amphetamine. Amphetamine 6 mg/kg body weight, enhanced the enzyme activity in the adrenal medulla. In cortical layers, the effect was different for various layers;...

Full description

Saved in:
Bibliographic Details
Published inArchives internationales de pharmacodynamie et de thérapie Vol. 302; p. 68
Main Authors Bhatnagar, M, Pandey, V N, Tewari, H B
Format Journal Article
LanguageEnglish
Published Belgium 01.11.1989
Subjects
Adrenal Cortex - anatomy & histology
Adrenal Cortex - drug effects
Adrenal Cortex - enzymology
Adrenal Glands - drug effects
Adrenal Glands - enzymology
Adrenal Medulla - anatomy & histology
Adrenal Medulla - drug effects
Adrenal Medulla - enzymology
Amphetamine - pharmacology
Animals
Butyrylcholinesterase - metabolism
Cholinesterases - metabolism
Female
Male
Mice
Online AccessGet more information

Cover

More Information
Summary:Butyrylcholinesterase (BChE, EC 3.1.1.8.) activity in adrenal cortex and medulla was studied in control mice and in mice treated with DL-amphetamine. Amphetamine 6 mg/kg body weight, enhanced the enzyme activity in the adrenal medulla. In cortical layers, the effect was different for various layers; the enzyme activity decreased in the zona glomerulosa and in the zona reticularis, but remained unaltered in the zona fasciculata. In view of various neuronal and nonneuronal functions of BChE, it is suggested that the difference in effect of amphetamine on activity of BChE in various parts of glands is due to the neuronal and nonneuronal origin and function of the adrenal medulla and the cortex.
ISSN:0003-9780