Fetal distribution of styrene in rats after vapor phase exposures

Pregnant rats were subjected to a 5-hour exposure of either 2,000 or 1,000 ppm atmospheres of styrene. Concentrations of styrene in the maternal blood and in each fetus were measured. The fetal concentrations in the 2,000 ppm exposure group were significantly more than double that in the 1,000 ppm g...

Full description

Saved in:
Bibliographic Details
Published inBiological research in pregnancy and perinatology Vol. 6; no. 2; p. 59
Main Authors Withey, J R, Karpinski, K
Format Journal Article
LanguageEnglish
Published Germany 1985
Subjects
Aerosols
Animals
Dose-Response Relationship, Drug
Female
Fetus - metabolism
Maternal-Fetal Exchange
Pregnancy
Rats
Rats, Inbred Strains
Styrene
Styrenes - administration & dosage
Styrenes - blood
Styrenes - metabolism
Tissue Distribution
Online AccessGet more information

Cover

More Information
Summary:Pregnant rats were subjected to a 5-hour exposure of either 2,000 or 1,000 ppm atmospheres of styrene. Concentrations of styrene in the maternal blood and in each fetus were measured. The fetal concentrations in the 2,000 ppm exposure group were significantly more than double that in the 1,000 ppm group. Fetal weight and distribution of styrene appear to be related to the fetal position on the uterine horn. Those at the ovarian and cervical ends of the uterine horn were of lowest weight and those at the ovarian end had the highest concentration of styrene. Concentrations of styrene appeared to be much lower in the fetuses than in maternal organs and tissues after similar exposures.
ISSN:0724-438X