Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes

• Published in: Pharmazie Vol. 56; no. 3; p. 242
• Main Authors: Kubínová, R, Machala, M, Minksová, K, Neca, J, Suchý, V
• Format: Journal Article
• Language: English
• Published: Germany 01.03.2001
• Subjects: Animals; Antioxidants - pharmacology; Aporphines - pharmacology; Brazil; Cell Line; Cytochrome P-450 CYP1A1 - antagonists & inhibitors; Cytochrome P-450 Enzyme System - metabolism; Glutathione Transferase - metabolism; In Vitro Techniques; Mice; Mice, Inbred C57BL; Microsomes, Liver - drug effects; Microsomes, Liver - enzymology; Mixed Function Oxygenases - metabolism; Pharmaceutical Preparations - metabolism; Plants, Medicinal - chemistry; Tumor Cells, Cultured; Brazil

Possible chemoprotective effects of the naturally occurring alkaloid boldine, a major alkaloid of boldo (Peumus boldus Mol.) leaves and bark, including in vitro modulations of drug-metabolizing enzymes in mouse hepatoma Hepa-1 cell line and mouse hepatic microsomes, were investigated. Boldine manife...