Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes

Possible chemoprotective effects of the naturally occurring alkaloid boldine, a major alkaloid of boldo (Peumus boldus Mol.) leaves and bark, including in vitro modulations of drug-metabolizing enzymes in mouse hepatoma Hepa-1 cell line and mouse hepatic microsomes, were investigated. Boldine manife...

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Bibliographic Details
Published inPharmazie Vol. 56; no. 3; p. 242
Main Authors Kubínová, R, Machala, M, Minksová, K, Neca, J, Suchý, V
Format Journal Article
LanguageEnglish
Published Germany 01.03.2001
Subjects
Animals
Antioxidants - pharmacology
Aporphines - pharmacology
Brazil
Cell Line
Cytochrome P-450 CYP1A1 - antagonists & inhibitors
Cytochrome P-450 Enzyme System - metabolism
Glutathione Transferase - metabolism
In Vitro Techniques
Mice
Mice, Inbred C57BL
Microsomes, Liver - drug effects
Microsomes, Liver - enzymology
Mixed Function Oxygenases - metabolism
Pharmaceutical Preparations - metabolism
Plants, Medicinal - chemistry
Tumor Cells, Cultured
Brazil
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Summary:Possible chemoprotective effects of the naturally occurring alkaloid boldine, a major alkaloid of boldo (Peumus boldus Mol.) leaves and bark, including in vitro modulations of drug-metabolizing enzymes in mouse hepatoma Hepa-1 cell line and mouse hepatic microsomes, were investigated. Boldine manifested inhibition activity on hepatic microsomal CYP1A-dependent 7-ethoxyresorufin O-deethylase and CYP3A-dependent testosterone 6 beta-hydroxylase activities and stimulated glutathione S-transferase activity in Hepa-1 cells. In addition to the known antioxidant activity, boldine could decrease the metabolic activation of other xenobiotics including chemical mutagens.
ISSN:0031-7144