Familial exercise-induced anaphylaxis

An 18-year-old hispanic male, his two brothers, father, two paternal uncles, and paternal grandfather experienced cutaneous and cardiorespiratory symptoms during vigorous exercise beginning at about 10 years of age. The propositus was challenged by running to exhaustion and by immersion in hot water...

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Bibliographic Details
Published inAnnals of allergy Vol. 54; no. 1; p. 35
Main Authors Grant, J A, Farnam, J, Lord, R A, Thueson, D O, Lett-Brown, M A, Wallfisch, H, Fine, D P, Schmalstieg, F C
Format Journal Article
LanguageEnglish
Published United States 01.01.1985
Subjects
Adolescent
Adult
Anaphylaxis - etiology
Anaphylaxis - genetics
Complement Activation
Histamine - blood
Histamine Release
Humans
Male
Mast Cells - metabolism
Pedigree
Physical Exertion
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Summary:An 18-year-old hispanic male, his two brothers, father, two paternal uncles, and paternal grandfather experienced cutaneous and cardiorespiratory symptoms during vigorous exercise beginning at about 10 years of age. The propositus was challenged by running to exhaustion and by immersion in hot water. In neither case were allergic signs or symptoms noted; however, plasma histamine rose from undetectable levels to 1.0 and 3.7 ng/ml, respectively. Furthermore, C2 and C5 were significantly reduced and fell during exercise.
ISSN:0003-4738