Pustular irritant dermatitis due to croton oil: evaluation of the role played by leukocytes and complement

To elucidate the pathomechanisms of irritant pustular dermatitis and to evaluate the role of leukocytes in pustulation induced by croton oil, we compared the skin responses in leukopenic-and decomplemented guinea pigs with those in control saline-injected animals, to 1% croton oil application. Both...

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Bibliographic Details
Published inActa dermato-venereologica Vol. 68; no. 3; pp. 257 - 260
Main Authors TORINUKI, W, TAGAMI, H
Format Journal Article
LanguageEnglish
Published Uppsala Acta dermato-venereologica 1988
Subjects
Administration, Cutaneous
Animals
Biological and medical sciences
Complement C5 - physiology
Complement C5a
Complement Inactivator Proteins - pharmacology
Croton Oil - administration & dosage
Croton Oil - toxicity
Dermatitis, Contact - etiology
Dermatitis, Contact - immunology
Dermatitis, Contact - pathology
Experimental and animal immunopathology. Animal models
Female
Guinea Pigs
Immunopathology
Leukocyte Count - methods
Leukocytes - physiology
Medical sciences
Time Factors
Immunopathology
Skin disease
Leukocyte
Pustulosis dermatosis
Rodentia
Croton oil
Complement
Vertebrata
Experimental disease
Mammalia
Guinea pig
Contact dermatitis
Irritant compound
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Summary:To elucidate the pathomechanisms of irritant pustular dermatitis and to evaluate the role of leukocytes in pustulation induced by croton oil, we compared the skin responses in leukopenic-and decomplemented guinea pigs with those in control saline-injected animals, to 1% croton oil application. Both decomplemented and control animals responded similarly to croton oil, showing erythema and pustulation at 24 h after topical application; microscopically numerous mononuclear and polymorphonuclear cells infiltrated the skin. Meanwhile, the clinical and histopathological response of leukopenic animals to croton oil was significantly depressed. Time-course study of inflammatory infiltrate in the dermis of controls revealed that mononuclear cells preceded the infiltration of polymorphonuclears. Although leukocytes constitute an important component in croton oil dermatitis, our results suggest that unclarified chemical mediators, other than complement-derived chemotactic factors, play a crucial role as a primary chemoattractant in the production of pustulation at the croton oil-applied site.
ISSN:0001-5555
1651-2057