Transgenic mouse model of X-linked cleft palate

A transgenic mouse line, PyLMP.5, exhibited a sex-linked lethality not observed in any other lines expressing the transgene. In this unique line, the transgene integrated into the X chromosome, yielding a simple tandem duplication of the insert sequences with minimal, if any, additional rearrangemen...

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Bibliographic Details
Published inCell growth & differentiation Vol. 4; no. 2; pp. 67 - 76
Main Authors WILSON, J. B, FERGUSON, M. W. J, JENKINS, N. A, LOCK, L. F, COPELAND, N. G, LEVINE, A. J
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 01.02.1993
Subjects
Animals
Biological and medical sciences
Biotechnology
Chromosome Mapping
Cleft Palate - genetics
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Genes, Lethal
Genetic engineering
Genetic Linkage
Genetic technics
Humans
Methods. Procedures. Technologies
Mice
Mice, Transgenic
Mutagenesis, Insertional
Pedigree
Phenotype
Transgenic animals
Transgenic animals and transgenic plants
X Chromosome
Sex linked character
Animal model
Vertebrata
Mammalia
Mouse
Insertion mutation
Rodentia
Transgenic animal
X-Chromosome
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Summary:A transgenic mouse line, PyLMP.5, exhibited a sex-linked lethality not observed in any other lines expressing the transgene. In this unique line, the transgene integrated into the X chromosome, yielding a simple tandem duplication of the insert sequences with minimal, if any, additional rearrangement of the cellular sequences. The predominant phenotype was a cleft secondary palate and neonatal lethality in males. Survival of females was dependent on the mouse strain background. The disrupted cellular sequences have been mapped to the proximal region of the mouse X chromosome. The disrupted locus may represent the mouse counterpart to a human locus mutated in an X-linked cleft secondary palate syndrome.
ISSN:1044-9523
2377-0732