Serum selenium levels in diuretic-treated hypertensives: a double-blind trial of piretanide against hydrochlorothiazide plus amiloride

In a double-blind parallel group study carried out on 47 patients with mild to moderate essential hypertension, the effects of 6 mg piretanide once or twice daily on serum selenium levels were compared with 50 mg hydrochlorothiazide plus 5 mg amiloride before treatment and after 6 and 12 weeks of tr...

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Bibliographic Details
Published inInternational journal of clinical pharmacology research Vol. 8; no. 1; p. 5
Main Authors Verho, M, Bossaller, W, Malerczyk, V
Format Journal Article
LanguageEnglish
Published Switzerland 1988
Subjects
Adult
Aged
Amiloride - therapeutic use
Clinical Trials as Topic
Diuretics - therapeutic use
Double-Blind Method
Humans
Hydrochlorothiazide - therapeutic use
Hypertension - complications
Hypertension - drug therapy
Middle Aged
Random Allocation
Selenium - blood
Sulfonamides - therapeutic use
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Summary:In a double-blind parallel group study carried out on 47 patients with mild to moderate essential hypertension, the effects of 6 mg piretanide once or twice daily on serum selenium levels were compared with 50 mg hydrochlorothiazide plus 5 mg amiloride before treatment and after 6 and 12 weeks of treatment. Serum levels of the trace element, selenium, over a treatment period of 12 weeks remained unchanged in all three treatment groups, indicating that the selenium homeostasis is not disturbed during a treatment period of three months with either piretanide or a potassium sparer/thiazide-diuretic combination.
ISSN:0251-1649