Synthesis and anthelmintic activity of carbamates derived from imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b]thiazole

The anthelmintic activity of 25 compounds, most of them carbamates, was determined. The in vitro results are interesting and show that an aromatic azapentalene can replace the benzimidazole ring without loss of its biological properties. The in vivo results, however, show that the compounds are devo...

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Bibliographic Details
Published inFarmaco (Società chimica italiana : 1989) Vol. 47; no. 1; p. 63
Main Authors Marin, A, Valls, N, Berenguer, F J, Alonso, M T, Ramon Martinez, A, Mercedes Martinez, M, Elguero, J
Format Journal Article
LanguageEnglish
Published France 01.01.1992
Subjects
Animals
Anthelmintics - chemical synthesis
Anthelmintics - pharmacology
Anthelmintics - therapeutic use
Antinematodal Agents - chemical synthesis
Antinematodal Agents - pharmacology
Caenorhabditis - drug effects
Carbamates - chemical synthesis
Carbamates - pharmacology
Imidazoles - chemical synthesis
Imidazoles - pharmacology
Imidazoles - therapeutic use
Mice
Nematoda - drug effects
Nematode Infections - drug therapy
Nematode Infections - parasitology
Structure-Activity Relationship
Thiadiazoles - chemical synthesis
Thiadiazoles - pharmacology
Thiadiazoles - therapeutic use
Thiazoles - chemical synthesis
Thiazoles - pharmacology
Thiazoles - therapeutic use
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Summary:The anthelmintic activity of 25 compounds, most of them carbamates, was determined. The in vitro results are interesting and show that an aromatic azapentalene can replace the benzimidazole ring without loss of its biological properties. The in vivo results, however, show that the compounds are devoid of practical interest.
ISSN:0014-827X