Nesosteine: a new mucoregulatory agent

A new, original molecule, nesosteine, modified both the rheology and the production of tracheobronchial mucus in rabbits. The drug highly significantly reduced the viscosity of tracheobronchial mucus in animals made bronchitic by H2SO4 aerosol and markedly increased mucoproduction in healthy animals...

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Bibliographic Details
Published inDrugs under experimental and clinical research Vol. 12; no. 8; p. 663
Main Authors Scuri, R, Mondani, P, Frova, C, Fantini, L
Format Journal Article
LanguageEnglish
Published Switzerland 1986
Subjects
Acetylcysteine - pharmacology
Animals
Bronchi - secretion
Expectorants - pharmacology
Male
Mucus - drug effects
Mucus - secretion
Rabbits
Terpenes - pharmacology
Thiazoles - pharmacology
Tiopronin - pharmacology
Trachea - secretion
Viscosity
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Summary:A new, original molecule, nesosteine, modified both the rheology and the production of tracheobronchial mucus in rabbits. The drug highly significantly reduced the viscosity of tracheobronchial mucus in animals made bronchitic by H2SO4 aerosol and markedly increased mucoproduction in healthy animals. Nesosteine was more active than the best known mucolytic/mucoregulatory drugs, such as sobrerol, N-acetylcysteine, bromexine, ambroxol, S-carboxymethylcysteine and mercaptopropionylglycine. The fluidifying activity of the drug was also demonstrated in vitro (pig's gastric mucin), although this proved to be less marked than in vivo. Nesosteine reduced the amount of total proteins of the tracheobronchial mucus, acting on albumin, alpha 1, alpha 2, beta and gamma mucoproteins.
ISSN:0378-6501