The nature of antiphospholipid antibodies

Despite the striking clinical manifestations associated with antiphospholipid antibodies (aPL) the role of these autoantibodies in disease and the nature of their true "inducing" and "target" antigens remain elusive. To address these issues, we investigated the immunogenic potent...

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Bibliographic Details
Published inJournal of rheumatology Vol. 19; no. 11; p. 1782
Main Authors Rauch, J, Janoff, A S
Format Journal Article
LanguageEnglish
Published Canada 01.11.1992
Subjects
Animals
Antibodies, Antiphospholipid - analysis
Antibodies, Antiphospholipid - immunology
Antibodies, Antiphospholipid - physiology
Mice
Mice, Inbred BALB C
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Summary:Despite the striking clinical manifestations associated with antiphospholipid antibodies (aPL) the role of these autoantibodies in disease and the nature of their true "inducing" and "target" antigens remain elusive. To address these issues, we investigated the immunogenic potential of phospholipid structures. To date, phospholipid immunogens have included hexagonal (II) forms of phosphatidylethanolamine and mixtures of apolipoprotein H (beta 2-glycoprotein I) with cardiolipin. Both hexagonal (II) phosphatidylethanolamine and the cardiolipin/apolipoprotein H mixture were capable of inducing aPL with lupus anticoagulant activity. Bilayer phosphatidylethanolamine and cardiolipin in the absence of apolipoprotein H were nonimmunogenic. Our data support our views that specific phospholipid structures are recognized by the immune system and that such structures serve as inducing and/or target antigens in the pathogenesis of aPL in vivo.
ISSN:0315-162X