Fate of cadmium bound to phytochelatin in rats

The fate cadmium(Cd) bound to phytochelatin [PC, (gamma-Glu-Cys)n-Gly)] was studied in rats using synthesized 109Cd-PC. Less Cd was absorbed through the digestive tracts than CdCl2, but the ratio of renal Cd to hepatic Cd was higher. After parenteral administration of Cd-PC, Cd was distributed mainl...

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Bibliographic Details
Published inResearch communications in chemical pathology and pharmacology Vol. 82; no. 3; p. 357
Main Authors Fujita, Y, el Belbasi, H I, Min, K S, Onosaka, S, Okada, Y, Matsumoto, Y, Mutoh, N, Tanaka, K
Format Journal Article
LanguageEnglish
Published United States 01.12.1993
Subjects
Absorption
Animals
Cadmium - administration & dosage
Cadmium - blood
Cadmium - pharmacokinetics
Cadmium Chloride
Chlorides - administration & dosage
Chlorides - blood
Chlorides - pharmacokinetics
Glutathione
Intestinal Absorption
Intestine, Small - metabolism
Kidney - metabolism
Liver - metabolism
Male
Metalloproteins - administration & dosage
Metalloproteins - blood
Metalloproteins - pharmacokinetics
Molecular Weight
Pancreas - metabolism
Phytochelatins
Plant Proteins - administration & dosage
Plant Proteins - blood
Plant Proteins - pharmacokinetics
Rats
Rats, Wistar
Tissue Distribution
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Summary:The fate cadmium(Cd) bound to phytochelatin [PC, (gamma-Glu-Cys)n-Gly)] was studied in rats using synthesized 109Cd-PC. Less Cd was absorbed through the digestive tracts than CdCl2, but the ratio of renal Cd to hepatic Cd was higher. After parenteral administration of Cd-PC, Cd was distributed mainly in the liver, kidney, small intestine and pancreas. More Cd was found in the kidney than the liver after Cd-PC (n = 5) administration. Most of the Cd was bound to the high molecular weight fraction in the hepatic cytosol 0.5 hr after administration and moved to the metallothionein fraction at 6 hr. The tissue distribution of Cd was not affected even when free PC (n = 5) was administered 3 hr after or before Cd injection. The distribution in the kidney increased only in the case of the simultaneous administration of Cd with PC. These findings show that the absorbance of Cd bound to PC from the alimentary tract is lower than that of CdCl2 although absorbed Cd is distributed to the kidney more than CdCl2, and Cd is liberated from PC soon after uptake by the cells.
ISSN:0034-5164