Study on the interaction between sucralfate and diclofenac/piroxicam in healthy volunteers

The possible interaction between sucralfate (Ulcogant, CAS 54182-58-0) on the one hand and diclofenac (CAS 15307-86-5) and piroxicam (CAS 36322-90-4) on the other hand was investigated in two groups each consisting of twelve healthy volunteers. The AUC (0-t) was calculated at 1670 +/- 492 ng/ml x h...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 41; no. 8; p. 797
Main Author Ungethüm, W
Format Journal Article
LanguageEnglish
Published Germany 01.08.1991
Subjects
Adult
Biological Availability
Diclofenac - pharmacokinetics
Diclofenac - pharmacology
Drug Interactions
Humans
Male
Middle Aged
Piroxicam - pharmacokinetics
Piroxicam - pharmacology
Random Allocation
Sucralfate - pharmacokinetics
Sucralfate - pharmacology
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Summary:The possible interaction between sucralfate (Ulcogant, CAS 54182-58-0) on the one hand and diclofenac (CAS 15307-86-5) and piroxicam (CAS 36322-90-4) on the other hand was investigated in two groups each consisting of twelve healthy volunteers. The AUC (0-t) was calculated at 1670 +/- 492 ng/ml x h for diclofenac alone and at 1817 +/- 682 ng/ml x h for diclofenac plus sucralfate. The mean AUC (0-t) for piroxicam alone was 91 +/- 19 micrograms/ml x h whilst that for piroxicam plus sucralfate was 91 +/- 20 micrograms/ml x h. The mean relative bioavailability was 116% for diclofenac plus sucralfate compared to diclofenac alone, and 100% for piroxicam plus sucralfate compared to piroxicam alone. Thus there is no interaction between sucralfate and diclofenac resp. piroxicam.
ISSN:0004-4172