Viminol R2 analgesic activity in patients with postoperative pain: comparison with pentazocine

The analgesic activity of Viminol R2 was compared to that of Pentazocine and placebo in a double-blind, "between subjects" study involving 42 patients with postoperative pain randomly assigned to 3 groups of 14 patients each and treated with a single intravenous dose of Viminol R2 10 mg, P...

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Bibliographic Details
Published inInternational journal of clinical pharmacology, therapy, and toxicology Vol. 24; no. 5; p. 232
Main Authors Cinelli, M, Costa, V, Ventresca, G P, Lodola, E
Format Journal Article
LanguageEnglish
Published Germany 01.05.1986
Subjects
Adult
Clinical Trials as Topic
Double-Blind Method
Drug Therapy, Combination
Ethanolamines - therapeutic use
Female
Humans
Male
Middle Aged
Pain, Postoperative - drug therapy
Pentazocine - adverse effects
Pentazocine - therapeutic use
Time Factors
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Summary:The analgesic activity of Viminol R2 was compared to that of Pentazocine and placebo in a double-blind, "between subjects" study involving 42 patients with postoperative pain randomly assigned to 3 groups of 14 patients each and treated with a single intravenous dose of Viminol R2 10 mg, Pentazocine 30 mg or placebo. Pain relief scores were recorded over a 2 h period after treatment. The analgesic activity of Viminol R2 and Pentazocine was significantly greater than that of placebo both in terms of time-course of action and frequency of classes of satisfactory analgesia. No statistically significant differences were found between Viminol R2 and Pentazocine. No side effects were observed in any patients treated with Viminol R2.
ISSN:0174-4879