The potential role of inflammatory and fibrogenic cytokines in the glomerular diseases

In recent years increasing evidence has been accumulated on the role of cytokines in mediating glomerular and renal damage. Many such cytokines are released in the inflamed glomeruli by leukocytes and intrinsic glomerular cells. Cytokines not only recruit inflammatory cells into the injured glomerul...

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Bibliographic Details
Published inJournal of lipid mediators and cell signalling Vol. 9; no. 1; p. 55
Main Authors Ortiz, A, Gómez-Chiarri, M, Alonso, J, Bustos, C, Gómez-Guerrero, C, López-Armada, M J, Gómez-Garre, D, Palacios, I, Ruíz-Ortega, M, Gutierrez, S
Format Journal Article
LanguageEnglish
Published Netherlands 01.02.1994
Subjects
Animals
Cytokines - biosynthesis
Cytokines - physiology
Glomerular Mesangium - immunology
Glomerular Mesangium - metabolism
Glomerulonephritis - immunology
Glomerulonephritis - physiopathology
Glomerulonephritis - therapy
Humans
Inflammation
Interleukin-1 - pharmacology
Interleukin-1 - physiology
Interleukin-6 - pharmacology
Interleukin-6 - physiology
Kidney Glomerulus - drug effects
Kidney Glomerulus - physiology
Kidney Glomerulus - physiopathology
Platelet-Derived Growth Factor - pharmacology
Platelet-Derived Growth Factor - physiology
Transforming Growth Factor beta - pharmacology
Transforming Growth Factor beta - physiology
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - pharmacology
Tumor Necrosis Factor-alpha - physiology
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Summary:In recent years increasing evidence has been accumulated on the role of cytokines in mediating glomerular and renal damage. Many such cytokines are released in the inflamed glomeruli by leukocytes and intrinsic glomerular cells. Cytokines not only recruit inflammatory cells into the injured glomeruli, but also induce a variety of responses on glomerular cells that range from a direct toxic effect to shape changes, proliferation, and induction of the release of inflammatory mediators and extracellular matrix, and could promote further glomerular damage. Moreover, exogenous administration of cytokines has induced glomerular injury in healthy animals and has enhanced renal damage in animals with glomerulonephritis. Anti-cytokine strategies have proved to be effective therapeutical alternatives in experimental models of glomerular diseases and may provide a more specific approach to the management of human glomerulonephritis.
ISSN:0929-7855