Chlorhexidine mouthwash-induced fixed drug eruption : case report and review of the literature

Various adverse reactions including anaphylactic shock have already been reported after the topical application of chlorhexidine. This article reports for the first time a hypersensitivity reaction in the form of fixed drug eruption after the use of a mouthwash containing chlorhexidine. This report...

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Bibliographic Details
Published inOral surgery, oral medicine, oral pathology Vol. 71; no. 4; pp. 431 - 434
Main Authors MOGHDAM, B. K. H, DRISKO, C. L, GIER, R. E
Format Journal Article
LanguageEnglish
Published Saint Louis, MO Mosby 01.04.1991
Subjects
Biological and medical sciences
Chlorhexidine - adverse effects
Chlorhexidine - analogs & derivatives
Drug Eruptions - etiology
Drug toxicity and drugs side effects treatment
Female
Foot Dermatoses - etiology
Hand Dermatoses - etiology
Humans
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
Mouthwashes - adverse effects
Pharmacology. Drug treatments
Placebos
Human
Case study
Skin disease
Toxicity
Fixed drug eruption
Hypersensitivity
Adult
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Summary:Various adverse reactions including anaphylactic shock have already been reported after the topical application of chlorhexidine. This article reports for the first time a hypersensitivity reaction in the form of fixed drug eruption after the use of a mouthwash containing chlorhexidine. This report should bring an increased awareness of the possibility of systemic hypersensitivity reaction to chlorhexidine in a previously sensitized person. The report also will add fixed drug eruption to the list of skin hypersensitivity reactions caused by chlorhexidine.
ISSN:0030-4220
1878-2175
DOI:10.1016/0030-4220(91)90424-B