Adrenergic reactivity of visceral veins in hypoxia and hypothermia

Adrenoreactivity of veins in skeletal muscle to norepinephrine decreased, while reactivity of intestinal veins remained virtually unchanged during combined exposure to hypoxia and hypothermia. In skeletal muscles cooling enhanced the direct effect of hypoxia on vascular smooth muscle cells, while in...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 130; no. 11; pp. 1063 - 1065
Main Authors Kudryashov, Y A, Tabarov, M S, Tkachenko, B T
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.11.2000
Subjects
Adrenergic alpha-Agonists - administration & dosage
Adrenergic alpha-Agonists - pharmacology
Animals
Arteries - physiopathology
Cats
Hypothermia - physiopathology
Hypothermia, Induced
Hypoxia
Hypoxia - physiopathology
Intestine, Small - blood supply
Muscle, Skeletal - blood supply
Norepinephrine - administration & dosage
Norepinephrine - pharmacology
Vascular Resistance
Veins & arteries
Veins - drug effects
Veins - physiopathology
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Summary:Adrenoreactivity of veins in skeletal muscle to norepinephrine decreased, while reactivity of intestinal veins remained virtually unchanged during combined exposure to hypoxia and hypothermia. In skeletal muscles cooling enhanced the direct effect of hypoxia on vascular smooth muscle cells, while in the intestine hypothermia prevented hypoxia-induced endothelial dysfunction, as it did under normothermic conditions. The results of experiments on the intestine indicated possible protective effect of hypothermia with respect to hypoxia-induced damage, and experimental findings on muscles showed potentiation of the direct effect of oxygen deficiency on venous smooth muscles.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0007-4888
1573-8221
DOI:10.1023/A:1002835432122