The outcome of pregnancy after chemotherapy for gestational trophoblastic disease

Thirteen pregnancies in 11 women previously treated with cytotoxic chemotherapy for GTD were studied. There were 11 live full-term babies (84.6%), 2 blighted ova (15.4%), 1 placenta accreta (7.7%) and 1 fetal anomaly (7.7%). Unlike other series, 69% of the pregnancies occurred within 1 year after th...

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Bibliographic Details
Published inBiological research in pregnancy and perinatology Vol. 6; no. 4; p. 177
Main Authors Hsieh, F J, Chen, T C, Cheng, Y T, Huang, S C, Hsieh, C Y, Ouyang, P C
Format Journal Article
LanguageEnglish
Published Germany 1985
Subjects
Abortion, Spontaneous
Adult
Antineoplastic Agents - therapeutic use
Congenital Abnormalities - complications
Congenital Abnormalities - epidemiology
Delivery, Obstetric
Female
Humans
Placenta Accreta - complications
Placenta Accreta - epidemiology
Pregnancy
Trophoblastic Neoplasms - drug therapy
Uterine Neoplasms - drug therapy
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Summary:Thirteen pregnancies in 11 women previously treated with cytotoxic chemotherapy for GTD were studied. There were 11 live full-term babies (84.6%), 2 blighted ova (15.4%), 1 placenta accreta (7.7%) and 1 fetal anomaly (7.7%). Unlike other series, 69% of the pregnancies occurred within 1 year after the termination of chemotherapy. The rate of successful pregnancy was not different from that reported by others. Prenatal elimination of abnormal embryos after conception rather than wastage of damaged oocyte before conception might explain this observed low incidence of abnormal birth in GTD patients treated with cytotoxic chemotherapy.
ISSN:0724-438X