In vitro studies of the loss of antibacterial activity of oxytetracycline in presence of Ca(II) or Mg(II) ions

• Published in: Arzneimittel-Forschung Vol. 46; no. 7; p. 701
• Main Authors: Naz, S, Khan, K A, Zubairi, S A
• Format: Journal Article
• Language: English
• Published: Germany 01.07.1996
• Subjects: Anti-Bacterial Agents - antagonists & inhibitors; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Bacillus - drug effects; Bacillus subtilis - drug effects; Bacteria - drug effects; Calcium - chemistry; Calcium - pharmacology; Magnesium - chemistry; Magnesium - pharmacology; Microbial Sensitivity Tests; Oxytetracycline - antagonists & inhibitors; Oxytetracycline - chemistry; Oxytetracycline - pharmacology; Staphylococcus aureus - drug effects
• ISSN: 0004-4172

The results of a comparative study, which evaluated the in vitro effect on the antibacterial activity of oxytetracycline (OTC, CAS 79-57-2) in presence of Ca(II)/Mg(II) ions suggest that susceptibility of Staphylococcus aureus, Bacillus pumilis and Bacillus subtilis to OTC is reduced in presence of Ca(II)/Mg(II) ions. As the ratio of concentration of Ca(II)/Mg(II) to OTC was increased, antibacterial activity of OTC declined. In addition to the difference observed between the antibacterial effect of pure OTC and its Ca(II)/Mg(II) complexes, it was found that decline in antibacterial activity is greater for Mg(II)-OTC complex than Ca(II)-OTC complex for the same concentration of Ca(II)/Mg(II) ions.