In vitro studies of the loss of antibacterial activity of oxytetracycline in presence of Ca(II) or Mg(II) ions

The results of a comparative study, which evaluated the in vitro effect on the antibacterial activity of oxytetracycline (OTC, CAS 79-57-2) in presence of Ca(II)/Mg(II) ions suggest that susceptibility of Staphylococcus aureus, Bacillus pumilis and Bacillus subtilis to OTC is reduced in presence of...

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Bibliographic Details
Published inArzneimittel-Forschung Vol. 46; no. 7; p. 701
Main Authors Naz, S, Khan, K A, Zubairi, S A
Format Journal Article
LanguageEnglish
Published Germany 01.07.1996
Subjects
Anti-Bacterial Agents - antagonists & inhibitors
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Bacillus - drug effects
Bacillus subtilis - drug effects
Bacteria - drug effects
Calcium - chemistry
Calcium - pharmacology
Magnesium - chemistry
Magnesium - pharmacology
Microbial Sensitivity Tests
Oxytetracycline - antagonists & inhibitors
Oxytetracycline - chemistry
Oxytetracycline - pharmacology
Staphylococcus aureus - drug effects
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Summary:The results of a comparative study, which evaluated the in vitro effect on the antibacterial activity of oxytetracycline (OTC, CAS 79-57-2) in presence of Ca(II)/Mg(II) ions suggest that susceptibility of Staphylococcus aureus, Bacillus pumilis and Bacillus subtilis to OTC is reduced in presence of Ca(II)/Mg(II) ions. As the ratio of concentration of Ca(II)/Mg(II) to OTC was increased, antibacterial activity of OTC declined. In addition to the difference observed between the antibacterial effect of pure OTC and its Ca(II)/Mg(II) complexes, it was found that decline in antibacterial activity is greater for Mg(II)-OTC complex than Ca(II)-OTC complex for the same concentration of Ca(II)/Mg(II) ions.
ISSN:0004-4172