A case of primary biliary cirrhosis associated with generalized morphea

A 50-year-old female with primary biliary cirrhosis associated with generalized morphea is reported. She had suffered from multiple painful indurated plaques on the trunk which was diagnosed as generalized morphea; subsequently, primary biliary cirrhosis was diagnosed on the basis of her hepatic dys...

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Published inHepato-gastroenterology Vol. 33; no. 5; p. 199
Main Authors Suyama, Y, Murawaki, Y, Horie, Y, Hirayama, C, Kanbe, N, Takenaka, M, Shimao, S, Ohta, G
Format Journal Article
LanguageEnglish
Published Greece 01.10.1986
Subjects
Female
Graft vs Host Disease - immunology
Humans
Liver Cirrhosis, Biliary - complications
Liver Cirrhosis, Biliary - immunology
Liver Cirrhosis, Biliary - pathology
Middle Aged
Scleroderma, Localized - complications
Scleroderma, Localized - immunology
Scleroderma, Localized - pathology
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Summary:A 50-year-old female with primary biliary cirrhosis associated with generalized morphea is reported. She had suffered from multiple painful indurated plaques on the trunk which was diagnosed as generalized morphea; subsequently, primary biliary cirrhosis was diagnosed on the basis of her hepatic dysfunction. Although progressive systemic sclerosis has been reported to occur in patients with primary biliary cirrhosis, this localized form of cutaneous sclerosis has not previously been reported. Since generalized morphea is one of the most common manifestations of chronic graft-versus-host disease, and primary biliary cirrhosis is known to have a hepatic histology resembling chronic graft-versus-host disease, this case report may represent evidence in support of a common pathogenesis for the two entities.
ISSN:0172-6390