Cytomorphologic, cytometric and histomorphologic observations after laser therapy for cervical lesions

To analyze the healing process after laser therapy for cervical lesions, the clinical, cytologic, histologic and colposcopic features in 109 cases were studied chronologically. The healing process of the cervical epithelium usually began from both the squamous and columnar epithelial borders, starti...

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Bibliographic Details
Published inJournal of reproductive medicine Vol. 37; no. 3; p. 267
Main Authors Hirai, Y, Nishide, K, Yamauchi, K, Fujimoto, I, Hasumi, K, Masubuchi, K, Dytch, H E
Format Journal Article
LanguageEnglish
Published United States 01.03.1992
Subjects
Biopsy
Cancer Care Facilities
Colposcopy
Cytological Techniques
DNA - analysis
Female
Flow Cytometry
Follow-Up Studies
Histological Techniques
Humans
Japan
Laser Therapy
Prognosis
Recurrence
Uterine Cervical Diseases - pathology
Uterine Cervical Diseases - physiopathology
Uterine Cervical Diseases - surgery
Wound Healing
Japan
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Summary:To analyze the healing process after laser therapy for cervical lesions, the clinical, cytologic, histologic and colposcopic features in 109 cases were studied chronologically. The healing process of the cervical epithelium usually began from both the squamous and columnar epithelial borders, starting around the 10th day after laser therapy; the process covered the whole tissue defect with multilayered epithelium within seven weeks. Inflammatory changes also usually abated within that time. Cytomorphologically, laser therapy resulted in the occurrence of (mostly degenerated) "fiber-type" and orangeophilic cells in smears taken during the first two weeks after treatment. Tissue repair cells were seen in smears collected from the first posttherapy day through the fourth week after laser therapy. Using computer-assisted image cytometry, the reparative cells in samples taken shortly after treatment (roughly, the first to fifth days) exhibited more hyperchromatic (3-4N) nuclei than did those in later samples; however, the mean DNA content of the early reparative cells was generally concentrated around that of the 2N reference cells. These findings suggest that follow-up, including cytologic and colposcopic examination, for the early detection of residual or recurrent lesions should start in the eighth week and continue periodically for at least one year.
ISSN:0024-7758