Importance of the mode of intravenous administration on cephotaxime concentration in bile. A comparison of bolus, drip infusion and bolus plus drip infusion

Success of antibacterial therapy depends on many factors, among which the level reached at the site of infection is important. Drug concentration in tissues and body fluids can be related to the mode of administration. The aim of the present work was to study the levels of cephotaxime (CFX) in bile,...

Full description

Saved in:
Bibliographic Details
Published inChemotherapy (Basel) Vol. 34; no. 5; p. 380
Main Authors Miglioli, P A, Tedeschi, U
Format Journal Article
LanguageEnglish
Published Switzerland 1988
Subjects
Aged
Bile - analysis
Bile - metabolism
Cefotaxime - administration & dosage
Cefotaxime - blood
Cefotaxime - pharmacokinetics
Female
Humans
Infusions, Intravenous
Injections, Intravenous
Male
Middle Aged
Online AccessGet more information

Cover

More Information
Summary:Success of antibacterial therapy depends on many factors, among which the level reached at the site of infection is important. Drug concentration in tissues and body fluids can be related to the mode of administration. The aim of the present work was to study the levels of cephotaxime (CFX) in bile, after intravenous administration of 1 g by bolus, drip infusion and bolus plus drip infusion. The drug was detected by a microbiological method. The results indicate that passage of CFX from blood into bile is a carrier-mediated process, and bolus, in the case of CFX, is the best mode of administration.
ISSN:0009-3157
DOI:10.1159/000238596