Anticardiolipin antibodies in acute rheumatic fever

Recent reports describe the association of antiphospholipid antibodies (aPL) with chorea or severe heart valve lesions in systemic lupus erythematosus, lupus-like disease, or the primary antiphospholipid antibody syndrome. We conducted a case series and a case-control investigation of patients with...

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Bibliographic Details
Published inJournal of rheumatology Vol. 19; no. 8; p. 1175
Main Authors Figueroa, F, Berríos, X, Gutiérrez, M, Carrión, F, Goycolea, J P, Riedel, I, Jacobelli, S
Format Journal Article
LanguageEnglish
Published Canada 01.08.1992
Subjects
Acute Disease
Adolescent
Adult
Antibodies, Anticardiolipin - analysis
Child
Chorea - complications
Chorea - immunology
Female
Humans
Immunoglobulin A - analysis
Immunoglobulin M - analysis
Male
Rheumatic Fever - complications
Rheumatic Fever - immunology
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Summary:Recent reports describe the association of antiphospholipid antibodies (aPL) with chorea or severe heart valve lesions in systemic lupus erythematosus, lupus-like disease, or the primary antiphospholipid antibody syndrome. We conducted a case series and a case-control investigation of patients with rheumatic fever with Sydenham chorea or other manifestations of rheumatic fever for anticardiolipin antibodies (aCL) during the acute attack and disease remission. Eighty percent of patients were positive for aCL during the rheumatic fever attack vs 40% when inactive (p = 0.035); IgG and IgM aCL increased significantly with disease activity. Individuals with or without Sydenham chorea were equally positive for aCL (76 and 83%, respectively). A significant association was found between IgM aCL and carditis: All patients with valvulitis had IgM aCL (100%) vs 37% of patients without valvular involvement (p = 0.02). aPL may play a role in the pathogenesis of some clinical manifestations of acute rheumatic fever.
ISSN:0315-162X
1499-2752