Heart transplantation in patients with heparin-induced thrombocytopenia on the Novacor left ventricular assist system

We report on two patients with development of heparin-induced thrombocytopenia with thrombosis while on the Novacor left ventricular assist system. Heart transplantation was successfully performed in both patients with heparin used for cardiopulmonary bypass after careful monitoring of heparin-assoc...

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Bibliographic Details
Published inThe Journal of heart and lung transplantation Vol. 17; no. 7; p. 729
Main Authors Brozena, S C, Twomey, C, Siegel, J, Peterson, P, Horrow, J C, Samuels, L, Morris, R
Format Journal Article
LanguageEnglish
Published United States 01.07.1998
Subjects
Anticoagulants - adverse effects
Cardiomyopathy, Dilated - therapy
Cardiopulmonary Bypass
Heart Transplantation
Heart-Assist Devices
Heparin - adverse effects
Humans
Male
Middle Aged
Myocardial Infarction - therapy
Thrombocytopenia - chemically induced
Thrombosis - chemically induced
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Summary:We report on two patients with development of heparin-induced thrombocytopenia with thrombosis while on the Novacor left ventricular assist system. Heart transplantation was successfully performed in both patients with heparin used for cardiopulmonary bypass after careful monitoring of heparin-associated antibodies. The approach to the patients' management and potential alternatives for anticoagulation are discussed.
ISSN:1053-2498
1557-3117