Effects of saponins of Panax notoginseng on sodium-potassium-adenosine triphosphatase and calcium-magnesium-adenosine triphosphatase

• Published in: Zhōngguó yàolĭ xuébào Vol. 12; no. 6; pp. 504 - 506
• Main Authors: Jin, L Q, Shi, L
• Format: Journal Article
• Language: English
• Published: Beijing Science Press 01.11.1991
• Subjects: Animals; Biological and medical sciences; Ca(2+) Mg(2+)-ATPase - metabolism; Calcium-Transporting ATPases - metabolism; Female; General pharmacology; Ginsenosides; Male; Medical sciences; Panax; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plants, Medicinal; Rats; Rats, Inbred Strains; Saponins - pharmacology; Sodium-Potassium-Exchanging ATPase - metabolism; Synaptosomes - enzymology; Calcium; Rat; Enzyme; Rodentia; Ca,Mg-ATPase; Central nervous system; In vitro; Medicinal plant; Saponin; Vertebrata; Synaptosome; Mammalia; Enzymatic activity; Dicotyledones; Animal; Angiospermae; Na,K-ATPase; Spermatophyta; Ion exchange; Mechanism of action; Araliaceae; Brain (vertebrata)
• ISSN: 0253-9756

Rat brain synaptosomal Na(+)-K(+)-ATPase was activated by Panax notoginseng (PNS, 0.1-1.0 mg.ml-1), fraction Rb1 (25-200 micrograms.ml-1), and fraction Rg1 (50-200 micrograms.ml-1). Activating rates were respectively 84-227%, 12-48%, and 12-22%. Results implied that Rb1 and Rg1 were not the major components of PNS, which were responsible for the activating effects. Ca(2+)-Mg(2+)-ATPase was inhibited by PNS (0.1-1.0 mg.ml-1) and Rb1 (100-200 micrograms.ml-1), but not by Rg1. It was proposed that PNS activated Na(+)-K(+)-ATPase, leading to a reduced Na+/Ca2+ exchange, a lowered intracellular Ca2+ level, and heart contractility.